Carcinoma of the Adrenal Cortex in a Rabbit

During the course of routine pathological examinations of 9 rabbits injected with relatively large amounts of the dye T-1824 (Evans blue), which is used for the determination of total plasma protein (Gregersen, Gibson, and Stead) and which has also been employed in therapeutic attempts in experimental cancer re.search (Brunschwig, Schmitz, and Jennings; DuranReynals), a bilateral tumor of the adrenals was found occurrence of adrenal tumors in gonadectomized male and female animals has focused special attention on these neoplasms (Hueper and Martin). The tumors were found in a male rabbit, weighing 2.4 kg., which had been injected intravenously with 3 cc./kg, of an 0.5 per cent Evans blue solution and which was killed approximately 6 months later. The postmortem examination showed that the upper in-